plosOne Computer science

• Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics 18 mai 2012
  by Anshuman Dixit, Gennady M. Verkhivker Deciphering functional mechanisms of the Hsp90 chaperone machinery is an important objective in cancer biology aiming to facilitate discovery of targeted anti-cancer therapies. Despite significant advances in understanding structure and function of molecular chaperones, organizing molecular principles that control the […]
  Anshuman Dixit et al.
• An Improved PSO Algorithm for Generating Protective SNP Barcodes in Breast Cancer 18 mai 2012
  by Li-Yeh Chuang, Yu-Da Lin, Hsueh-Wei Chang, Cheng-Hong Yang Background Possible single nucleotide polymorphism (SNP) interactions in breast cancer are usually not investigated in genome-wide association studies. Previously, we proposed a particle swarm optimization (PSO) method to compute these kinds of SNP interactions. However, this PSO does not guarante […]
  Li-Yeh Chuang et al.
• Assessment Method for a Power Analysis to Identify Differentially Expressed Pathways 18 mai 2012
  by Shailesh Tripathi, Frank Emmert-Streib Gene expression data can provide a very rich source of information for elucidating the biological function on the pathway level if the experimental design considers the needs of the statistical analysis methods. The purpose of this paper is to provide a comparative analysis of statistical methods for detecting the di […]
  Shailesh Tripathi et al.
• arrayMap: A Reference Resource for Genomic Copy Number Imbalances in Human Malignancies 18 mai 2012
  by Haoyang Cai, Nitin Kumar, Michael Baudis Background The delineation of genomic copy number abnormalities (CNAs) from cancer samples has been instrumental for identification of tumor suppressor genes and oncogenes and proven useful for clinical marker detection. An increasing number of projects have mapped CNAs using high-resolution microarray based techni […]
  Haoyang Cai et al.
• Feasibility of Prehospital Teleconsultation in Acute Stroke – A Pilot Study in Clinical Routine 18 mai 2012
  by Sebastian Bergrath, Arno Reich, Rolf Rossaint, Daniel Rörtgen, Joachim Gerber, Harold Fischermann, Stefan K. Beckers, Jörg C. Brokmann, Jörg B. Schulz, Claas Leber, Christina Fitzner, Max Skorning Background Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), the feasibility and effects […]
  Sebastian Bergrath et al.
• A Novel Generalized Normal Distribution for Human Longevity and other Negatively Skewed Data 18 mai 2012
  by Henry T. Robertson, David B. Allison Negatively skewed data arise occasionally in statistical practice; perhaps the most familiar example is the distribution of human longevity. Although other generalizations of the normal distribution exist, we demonstrate a new alternative that apparently fits human longevity data better. We propose an alternative appro […]
  Henry T. Robertson et al.
• Modelling the Spatio-Temporal Cell Dynamics Reveals Novel Insights on Cell Differentiation and Proliferation in the Small Intestinal Crypt 18 mai 2012
  by Carmen Pin, Alastair J. M. Watson, Simon R. Carding We developed a slow structural relaxation model to describe cellular dynamics in the crypt of the mouse small intestine. Cells are arranged in a three dimensional spiral the size of which dynamically changes according to cell production demands of adjacent villi. Cell differentiation and proliferation is […]
  Carmen Pin et al.
• Algebraic Comparison of Partial Lists in Bioinformatics 17 mai 2012
  by Giuseppe Jurman, Samantha Riccadonna, Roberto Visintainer, Cesare Furlanello The outcome of a functional genomics pipeline is usually a partial list of genomic features, ranked by their relevance in modelling biological phenotype in terms of a classification or regression model. Due to resampling protocols or to a meta-analysis comparison, it is often the […]
  Giuseppe Jurman et al.
• Stochastic Frontier Model Approach for Measuring Stock Market Efficiency with Different Distributions 17 mai 2012
  by Md. Zobaer Hasan, Anton Abdulbasah Kamil, Adli Mustafa, Md. Azizul Baten The stock market is considered essential for economic growth and expected to contribute to improved productivity. An efficient pricing mechanism of the stock market can be a driving force for channeling savings into profitable investments and thus facilitating optimal allocation of c […]
  Md. Zobaer Hasan et al.
• Using Knowledge Fusion to Analyze Avian Influenza H5N1 in East and Southeast Asia 17 mai 2012
  by Erjia Ge, Robert Haining, Chi Pang Li, Zuguo Yu, Miu Yee Waye, Ka Hou Chu, Yee Leung Highly pathogenic avian influenza (HPAI) H5N1, a disease associated with high rates of mortality in infected human populations, poses a serious threat to public health in many parts of the world. This article reports findings from a study aimed at improving our understand […]
  Erjia Ge et al.